Subjects in Part B (N=6, randomized 4:2 drug:placebo) received 4 doses of ALN-AAT at 1 mg/kg administered every 28 days. ALN-AAT administration resulted in potent, dose-dependent and durable knockdown of serum AAT. A single 6 mg/kg dose of ALN-AAT attained an AAT knockdown of up to 88.9% with a mean maximal knockdown of 83.9 2.6%. The pharmacodynamic effects of ALN-AAT were highly durable, where a single dose at 6 mg/kg maintained mean AAT knockdown of 75.0 1.2% at approximately six months. ALN-AAT was shown to be generally well tolerated in healthy adult volunteers. There were no drug-related serious adverse events (SAEs), discontinuations due to adverse events (AEs), or injection site reactions reported. Transient, asymptomatic, and dose-dependent increases in liver enzymes were observed in 3 out of 15 healthy volunteers exposed to single doses of ALN-AAT. Since the target patient population for ALN-AAT has established liver disease, Alnylam plans to advance a follow-on molecule targeting a different sequence for further development. Specifically, the Company is finalizing selection of a new Development Candidate ALN-AAT02 and plans to rapidly advance this compound towards the clinic, with a planned CTA filing in 2017. Read More In addition, several posters were presented by Alnylam researchers describing significant advances made in optimizing Alnylams Enhanced Stabilization Chemistry (ESC)-GalNAc platform, including improved potency, duration of activity, and tolerability, based on a greater mechanistic understanding of GalNAc conjugate features.
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(AP) Tennessee linebacker Darrin Kirkland Jr. will miss a third straight game Saturday at No. 25 Georgia because of a high ankle sprain. Volunteers coach Butch Jones ruled out Kirkland on Wednesday. Jones said he expects defensive end LaTroy Lewis to play for the 11th-ranked Volunteers this week. Lewis played sparingly Saturday in a 38-28 victory over Florida after missing the Sept. 17 win over Ohio with an ankle injury. The Vols also are hoping linebacker Jalen Reeves-Maybin can play this week after he missed the majority of Tennessees last two games with a shoulder injury. http://milwaukeehybridgroup.com/milwaukeehybridgroupcom7826/2016/09/21/sometimes-the-first-2-toes-will-cross-over-making-it-hard-to-walk/Jones said Wednesday night on his Vol Calls radio show that Reeves-Maybin had another MRI so were waiting on word from there to see how his health is progressing. Jones had said earlier in the day that he expected Reeves-Maybin to play against Georgia. Cornerback Cam Sutton remains sidelined after fracturing his right ankle Sept. 17.
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Barium X-ray helps get a clear image of the digestive tract. The FDA has received more than 6,000 reports of serious side effects of the drug and dog owners should know that the drug can even kill their dog; if it is not prescribed by your vet and if it is not administered under the guidance of your vet. Secondly, the doctor might ask the patient if there is blood in stools. It’s an autoimmune disorder in which the body’s immune system attacks its own antibodies, i.e. white blood cells in the joint fluid, leading to different types of medical problems. Granulomatous reaction is a common symptom of Cohn’s disease, which is a close relative of the inflammatory bowel disease and causes the inflammation of parts of the digestive tract, right from that mouth to the gut, inflammation of stomach lining is also observed in such a case. If the allergic reaction is due to a medical condition known as anaphylaxis, then it needs immediate medical attention since it is a potentially harmful disease. This can lead to serious health problems like arthritis, diabetes, or even cancer. Instead, eating lean meat is a safer option to prevent inflammation. Surgical means are used to remove certain infected regions of the bowels. have a peek at this web-site